Submissions for variant NM_002691.4(POLD1):c.2565-17G>A

gnomAD frequency: 0.00078  dbSNP: rs200576676

Total submissions: 7

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Counsyl	RCV000410659	SCV000489441	likely benign	Colorectal cancer, susceptibility to, 10	2016-10-04	criteria provided, single submitter	clinical testing
GeneDx	RCV000434439	SCV000521325	likely benign	not specified	2017-07-17	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
PreventionGenetics, part of Exact Sciences	RCV000679498	SCV000806505	likely benign	not provided	2017-07-27	criteria provided, single submitter	clinical testing
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden	RCV000679498	SCV002010409	uncertain significance	not provided	2021-11-03	criteria provided, single submitter	clinical testing
Invitae	RCV000410659	SCV002422458	benign	Colorectal cancer, susceptibility to, 10	2024-01-29	criteria provided, single submitter	clinical testing
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital	RCV000434439	SCV002551970	uncertain significance	not specified	2024-02-06	criteria provided, single submitter	clinical testing
KCCC/NGS Laboratory, Kuwait Cancer Control Center	RCV000410659	SCV004016661	likely benign	Colorectal cancer, susceptibility to, 10	2023-07-07	criteria provided, single submitter	clinical testing