ClinVar Miner

Submissions for variant NM_002834.3(PTPN11):c.*13A>G (rs201957261)

Minimum review status: Collection method:
Minimum conflict level:
ClinVar version:
Total submissions: 2
Download table as spreadsheet
Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000127658 SCV000171237 benign not specified 2013-10-07 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Laboratory for Molecular Medicine,Partners HealthCare Personalized Medicine RCV000127658 SCV000270773 likely benign not specified 2015-10-13 criteria provided, single submitter clinical testing c.*13A>G in the 3'UTR of PTPN11: This variant is not expected to have clinical significance because it has been identified in 0.1% (43/62072) of European chrom osomes by the Exome Aggregation Constortium (ExAC, http://exac.broadinstitute.or g; dbSNP rs201957261).

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.