ClinVar Miner

Submissions for variant NM_002834.4(PTPN11):c.853T>G (p.Phe285Val) (rs397507531)

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Total submissions: 1
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago RCV001027842 SCV001190462 likely pathogenic Noonan syndrome 1; Metachondromatosis; LEOPARD syndrome 1 2019-10-24 criteria provided, single submitter clinical testing PTPN11 NM_002834.4 exon 7 p.Phe285Val (c.853T>G): This variant has not been reported in the literature and is not present in large control databases. Evolutionary conservation and computational predictive tools suggest that this variant may impact the protein. Additionally, other variants at the same amino acid residue (Phe285Cys, Phe285Ile, Phe285Leu, Phe285Ser) have also been reported in association with disease, further supporting that this region has significance (Tartilglia 2002 PMID:11992261, Tartiglia 2006 PMID:16358218, Ferrero 2008 PMID:18678287, Hakami 2016 PMID:26918529). In summary, data on this variant is highly suspicious for disease, but requires further evidence for pathogenicity. Therefore, this variant is classified as likely pathogenic.

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