ClinVar Miner

Submissions for variant NM_002878.3(RAD51D):c.695G>A (p.Arg232Gln) (rs28363283)

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Total submissions: 9
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000127695 SCV000213965 benign Hereditary cancer-predisposing syndrome 2014-08-07 criteria provided, single submitter clinical testing Lines of evidence used in support of classification: General population or subpopulation frequency is too high to be a pathogenic mutation based on disease/syndrome prevalence and penetrance
Color RCV000127695 SCV000686481 benign Hereditary cancer-predisposing syndrome 2014-12-23 criteria provided, single submitter clinical testing
Counsyl RCV000205175 SCV000488478 likely benign Breast-ovarian cancer, familial 4 2016-06-13 criteria provided, single submitter clinical testing
GeneDx RCV000212966 SCV000171274 benign not specified 2014-02-11 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae RCV000205175 SCV000261683 benign Breast-ovarian cancer, familial 4 2018-01-05 criteria provided, single submitter clinical testing
PreventionGenetics RCV000212966 SCV000806584 benign not specified 2017-06-20 criteria provided, single submitter clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano RCV000212966 SCV000602165 benign not specified 2017-06-28 criteria provided, single submitter clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano RCV000760068 SCV000889831 benign not provided 2017-06-28 criteria provided, single submitter clinical testing
True Health Diagnostics RCV000127695 SCV000788208 likely benign Hereditary cancer-predisposing syndrome 2017-09-13 no assertion criteria provided clinical testing

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