ClinVar Miner

Submissions for variant NM_002878.3(RAD51D):c.983C>T (p.Thr328Ile) (rs138969595)

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Total submissions: 7
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000129828 SCV000184643 likely benign Hereditary cancer-predisposing syndrome 2017-09-13 criteria provided, single submitter clinical testing Lines of evidence used in support of classification: Subpopulation frequency in support of benign classification,Other data supporting benign classification
Color RCV000129828 SCV000902869 likely benign Hereditary cancer-predisposing syndrome 2016-04-28 criteria provided, single submitter clinical testing
Counsyl RCV000411668 SCV000488575 uncertain significance Breast-ovarian cancer, familial 4 2016-06-09 criteria provided, single submitter clinical testing
GeneDx RCV000254688 SCV000211662 likely benign not specified 2017-08-07 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Illumina Clinical Services Laboratory,Illumina RCV000331029 SCV000401962 uncertain significance Breast and Ovarian Cancer Susceptibility 2016-06-14 criteria provided, single submitter clinical testing
Invitae RCV000411668 SCV000551327 likely benign Breast-ovarian cancer, familial 4 2017-12-15 criteria provided, single submitter clinical testing
Mendelics RCV000709425 SCV000839167 uncertain significance Hereditary breast and ovarian cancer syndrome 2018-07-02 criteria provided, single submitter clinical testing

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