ClinVar Miner

Submissions for variant NM_002878.4(RAD51D):c.263+1605G>A

gnomAD frequency: 0.00023  dbSNP: rs147933658
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Total submissions: 8
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000127703 SCV000171282 benign not specified 2014-02-21 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Counsyl RCV000411943 SCV000489548 likely benign Breast-ovarian cancer, familial, susceptibility to, 4 2016-10-19 criteria provided, single submitter clinical testing
Color Diagnostics, LLC DBA Color Health RCV000580135 SCV000686436 likely benign Hereditary cancer-predisposing syndrome 2015-06-15 criteria provided, single submitter clinical testing
Mendelics RCV000411943 SCV001140421 likely benign Breast-ovarian cancer, familial, susceptibility to, 4 2019-05-28 criteria provided, single submitter clinical testing
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories RCV000411943 SCV002048486 likely benign Breast-ovarian cancer, familial, susceptibility to, 4 2021-04-02 criteria provided, single submitter clinical testing
CeGaT Center for Human Genetics Tuebingen RCV004567072 SCV005050253 likely benign not provided 2025-02-01 criteria provided, single submitter clinical testing RAD51D: BP4, BS1
Breakthrough Genomics, Breakthrough Genomics RCV004567072 SCV005214641 likely benign not provided criteria provided, single submitter not provided
PreventionGenetics, part of Exact Sciences RCV003935203 SCV004749051 likely benign RAD51D-related disorder 2022-11-10 no assertion criteria provided clinical testing This variant is classified as likely benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).

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