ClinVar Miner

Submissions for variant NM_002878.4(RAD51D):c.66C>T (p.Ser22=)

dbSNP: rs876660902
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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000215440 SCV000278702 likely benign Hereditary cancer-predisposing syndrome 2021-01-20 criteria provided, single submitter clinical testing This alteration is classified as likely benign based on a combination of the following: seen in unaffected individuals, population frequency, intact protein function, lack of segregation with disease, co-occurrence, RNA analysis, in silico models, amino acid conservation, lack of disease association in case-control studies, and/or the mechanism of disease or impacted region is inconsistent with a known cause of pathogenicity.
Labcorp Genetics (formerly Invitae), Labcorp RCV001089211 SCV000651770 likely benign Breast-ovarian cancer, familial, susceptibility to, 4 2024-10-27 criteria provided, single submitter clinical testing
Color Diagnostics, LLC DBA Color Health RCV000215440 SCV000691355 likely benign Hereditary cancer-predisposing syndrome 2017-09-26 criteria provided, single submitter clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano RCV000760067 SCV000889829 likely benign not provided 2018-05-04 criteria provided, single submitter clinical testing

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