Submissions for variant NM_002878.4(RAD51D):c.921G>A (p.Glu307=)

dbSNP: rs1057523377

Total submissions: 5

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
GeneDx	RCV000421241	SCV000531726	likely benign	not specified	2016-09-08	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Labcorp Genetics (formerly Invitae), Labcorp	RCV000870343	SCV001011835	likely benign	Breast-ovarian cancer, familial, susceptibility to, 4	2024-06-15	criteria provided, single submitter	clinical testing
Ambry Genetics	RCV001019027	SCV001180332	likely benign	Hereditary cancer-predisposing syndrome	2018-05-30	criteria provided, single submitter	clinical testing	This alteration is classified as likely benign based on a combination of the following: seen in unaffected individuals, population frequency, intact protein function, lack of segregation with disease, co-occurrence, RNA analysis, in silico models, amino acid conservation, lack of disease association in case-control studies, and/or the mechanism of disease or impacted region is inconsistent with a known cause of pathogenicity.
Color Diagnostics, LLC DBA Color Health	RCV001019027	SCV001349816	likely benign	Hereditary cancer-predisposing syndrome	2019-08-12	criteria provided, single submitter	clinical testing
Sema4, Sema4	RCV001019027	SCV002527052	likely benign	Hereditary cancer-predisposing syndrome	2021-10-05	criteria provided, single submitter	curation