ClinVar Miner

Submissions for variant NM_002880.4(RAF1):c.1108+15C>T

gnomAD frequency: 0.00003  dbSNP: rs727503383
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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine RCV000151710 SCV000200034 likely benign not specified 2014-08-18 criteria provided, single submitter clinical testing 1108+15C>T in intron 10 of RAF1: This variant is not expected to have clinical significance because a C>T change at this position does not diverge from the spl ice consensus sequence and is therefore unlikely to impact splicing.
Labcorp Genetics (formerly Invitae), Labcorp RCV002514922 SCV002933952 likely benign RASopathy 2023-12-21 criteria provided, single submitter clinical testing

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