Total submissions: 2
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Gene |
RCV000486229 | SCV000565569 | likely pathogenic | not provided | 2016-02-10 | criteria provided, single submitter | clinical testing | The P281L missense change likely associated with primary/systemic carnitine deficiency (PCD) was identified in the SLC22A5 gene. It has not been published as a pathogenic variant, nor has it been reported as a benign polymorphism to our knowledge. The amino acid change is semi-conservative because both Proline and Leucine are uncharged, non-polar amino acids, but the replacement of a Proline with its unique ring structure could affect the secondary structure and function of the SLC22A5 protein. This change occurs at a highly conserved position in the SLC22A5 protein, and multiple missense variants at neighboring positions (S280F, R282Q, W283R, W283C) have been reported in association with PCD according to the Human Gene Mutation Database. Furthermore, multiple in-silico analysis programs predict that P281L is damaging to the SLC22A5 protein. Therefore, P281L is a strong candidate for a disease-causing variant, however the possibility that it is a benign variant cannot be excluded. |
Counsyl | RCV000984307 | SCV001132487 | uncertain significance | Renal carnitine transport defect | 2018-12-18 | no assertion criteria provided | clinical testing |