Total submissions: 3
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Women's Health and Genetics/Laboratory Corporation of America, |
RCV000022912 | SCV001360665 | pathogenic | Nicolaides-Baraitser syndrome | 2019-11-04 | criteria provided, single submitter | clinical testing | Variant summary: SMARCA2 c.3475C>G (p.Arg1159Gly) results in a non-conservative amino acid change located in the Helicase, C-terminal domain (IPR001650) of the encoded protein sequence. Five of five in-silico tools predict a damaging effect of the variant on protein function. The variant was absent in 250800 control chromosomes (gnomAD). c.3475C>G has been reported in the literature in individuals affected with Nicolaides-Baraitser syndrome (e.g. VanHoudt_2012, Sousa_2014), and was detected as a de-novo mutation in at least one of these patients (VanHoudt_2012). These data indicate that the variant may be associated with disease. To our knowledge, no experimental evidence demonstrating an impact on protein function has been reported. No clinical diagnostic laboratories have submitted clinical-significance assessments for this variant to ClinVar after 2014. In addition, p.R1159Q and p.R1159L have been reported in patients with Nicolaides-Baraitser syndrome (HGMD database). Based on the evidence outlined above, the variant was classified as pathogenic. |
OMIM | RCV000022912 | SCV000044203 | pathogenic | Nicolaides-Baraitser syndrome | 2012-02-26 | no assertion criteria provided | literature only | |
Uni |
RCV000059675 | SCV000091245 | not provided | not provided | no assertion provided | not provided |