Submissions for variant NM_003200.5(TCF3):c.315G>A (p.Arg105=)

gnomAD frequency: 0.00160  dbSNP: rs144176765

Total submissions: 7

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Labcorp Genetics (formerly Invitae), Labcorp	RCV000892682	SCV001036575	benign	not provided	2025-02-03	criteria provided, single submitter	clinical testing
Fulgent Genetics, Fulgent Genetics	RCV002505286	SCV002801557	likely benign	Agammaglobulinemia 8, autosomal dominant; Agammaglobulinemia 8b, autosomal recessive	2021-10-05	criteria provided, single submitter	clinical testing
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories	RCV000892682	SCV005876106	likely benign	not provided	2024-11-23	criteria provided, single submitter	clinical testing
CeGaT Center for Human Genetics Tuebingen	RCV000892682	SCV005909823	likely benign	not provided	2025-03-01	criteria provided, single submitter	clinical testing	TCF3: BP4, BP7
Genome Diagnostics Laboratory, University Medical Center Utrecht	RCV000892682	SCV001931875	likely benign	not provided		no assertion criteria provided	clinical testing
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center	RCV000892682	SCV001974019	likely benign	not provided		no assertion criteria provided	clinical testing
PreventionGenetics, part of Exact Sciences	RCV003910623	SCV004720969	likely benign	TCF3-related disorder	2019-12-17	no assertion criteria provided	clinical testing	This variant is classified as likely benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).