Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Labcorp Genetics |
RCV005134880 | SCV005761904 | uncertain significance | Arthrogryposis, distal, type 1A | 2024-07-16 | criteria provided, single submitter | clinical testing | This sequence change replaces aspartic acid, which is acidic and polar, with histidine, which is basic and polar, at codon 14 of the TPM2 protein (p.Asp14His). This variant is not present in population databases (gnomAD no frequency). This variant has not been reported in the literature in individuals affected with TPM2-related conditions. An algorithm developed to predict the effect of missense changes on protein structure and function (PolyPhen-2) suggests that this variant is likely to be disruptive. This variant disrupts the p.Asp14 amino acid residue in TPM2. Other variant(s) that disrupt this residue have been determined to be pathogenic (PMID: 22980765, 24692096; Invitae). This suggests that this residue is clinically significant, and that variants that disrupt this residue are likely to be disease-causing. In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance. |