Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Laboratory for Molecular Medicine, |
RCV000154660 | SCV000204337 | likely pathogenic | Primary dilated cardiomyopathy | 2015-05-20 | criteria provided, single submitter | clinical testing | The p.Ser23240fs variant in TTN has been identified by our laboratory in 1 Cauca sian individual with DCM as well as in 1 affected relative. It was absent from l arge population studies. This variant is predicted to cause a frameshift, which alters the protein?s amino acid sequence beginning at position 23240 and leads t o a premature termination codon 19 amino acids downstream. This alteration is th en predicted to lead to a truncated or absent protein. Frameshift and other trun cating variants in TTN are strongly associated with DCM if they are located in t he exons encoding for the A-band (Herman 2012, Pugh 2014) and/or are located in an exon that is highly expressed in the heart (Roberts 2015). The p.Ser23240fs v ariant is located in A-band in the highly expressed exon 275. In summary, althou gh additional studies are required to fully establish its clinical significance, the p.Ser23240fs variant is likely pathogenic. |