ClinVar Miner

Submissions for variant NM_003331.4(TYK2):c.[-1307T>A;-1308G>A-316G>A-317G>A-378A>G-482A>C]

Minimum review status: Collection method:
Minimum conflict level:
ClinVar version:
Total submissions: 1
Download table as spreadsheet
Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Division of Host Defense, Kyushu University RCV000508928 SCV000606721 risk factor Virus-induced diabetes no assertion criteria provided reference population rs953883300, rs2304259, rs17000730, rs17000728, rs2304258 and variant NC_000019.10:g.10381501A>T are in complete linkage disequilibriumin, the haplotype was named TYK2 Promoter Variant. The entire haplotype is the risk factor for Virus-induced type 1 diabetes in Japanese. These SNPs cause mild decrease of anti-viral response.

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.