Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Rady Children's Institute for Genomic Medicine, |
RCV001733827 | SCV001984814 | pathogenic | Kabuki syndrome 1 | 2020-08-12 | criteria provided, single submitter | clinical testing | This variant affects the canonical splice acceptor site of intron 53 and is therefore predicted to interfere with splicing and result in loss of normal protein function through either protein truncation or nonsense-mediated mRNA decay (NMD). This variant has not been previously reported or functionally characterized in the literature to our knowledge. This alteration is located at the C-terminal portion of KMT2D that includes the SET domain with histone methyltransferase activity (PMID: 28669924). Other splicing alterations within intron 53 have been reported in individuals with Kabuki Syndrome (PMID: 28475860, 29304373). This variant is absent from the gnomAD population database and thus is presumed to be rare. Analysis of the parental samples was negative for the variant, indicating this variant likely occurred as a de novo event. Based on the available evidence, the c.16522-5_16522-2del variant is classified as Pathogenic. |