ClinVar Miner

Submissions for variant NM_003667.4(LGR5):c.286C>T (p.Arg96Cys)

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Total submissions: 1
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV005347607 SCV006025276 uncertain significance not specified 2025-03-07 criteria provided, single submitter clinical testing The c.286C>T (p.R96C) alteration is located in exon 3 (coding exon 3) of the LGR5 gene. This alteration results from a C to T substitution at nucleotide position 286, causing the arginine (R) at amino acid position 96 to be replaced by a cysteine (C). Based on insufficient or conflicting evidence, the clinical significance of this alteration remains unclear.

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