Total submissions: 2
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Mendelics | RCV002249867 | SCV002519496 | pathogenic | Becker muscular dystrophy | 2022-05-04 | criteria provided, single submitter | clinical testing | |
Prevention |
RCV004529109 | SCV004106979 | uncertain significance | DMD-related disorder | 2023-07-29 | criteria provided, single submitter | clinical testing | The DMD c.10223+4A>G variant is predicted to interfere with splicing. In an alternate transcript, this variant leads to protein extension through removal of the stop codon (NM_004019.2:c.1023A>G (p.*341Trpext*11)). To our knowledge, this variant has not been reported in the literature or in a large population database (http://gnomad.broadinstitute.org), indicating this variant is rare. It is interpreted as pathogenic by a single submission in ClinVar; however, no supporting evidence was provided (preview.ncbi.nlm.nih.gov/clinvar/variation/1685700/). Numerous other splicing variants have been reported as causative at this splice junction in the Human Gene Mutation Database (HGMD) and Leiden Open Variation Database (LOVD), including many outside of the canonical splice site, at the +3, +5, and +6 positions (HGMD; LOVD; Neri et al. 2020. PubMed ID: 32194622). Although we suspect that this variant may be pathogenic, at this time, the clinical significance of this variant is uncertain due to the absence of conclusive functional and genetic evidence. |