Total submissions: 2
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Gene |
RCV000033290 | SCV000057195 | pathogenic | not provided | 2024-11-22 | criteria provided, single submitter | clinical testing | Not observed at significant frequency in large population cohorts (gnomAD); Missense variants in this gene are a common cause of disease and they are underrepresented in the general population; In silico analysis indicates that this missense variant does not alter protein structure/function; This variant is associated with the following publications: (PMID: 24803665, 30141192, 37697822, 36347258, 24957944, 15488754, 16439621, 15520807, 17603483, 29493581, 37697378, 18042262) |
Women's Health and Genetics/Laboratory Corporation of America, |
RCV001193980 | SCV001363182 | likely pathogenic | RASopathy | 2019-04-29 | criteria provided, single submitter | clinical testing | Variant summary: BRAF c.784C>A (p.Gln262Lys) results in a conservative amino acid change located in the Protein kinase C-like, phorbol ester/diacylglycerol-binding domain (IPR002219) of the encoded protein sequence. Three of five in-silico tools predict a benign effect of the variant on protein function. The variant was absent in 251244 control chromosomes (gnomAD). c.784C>A has been reported in the literature as de novo occurrence in an individual affected with cardio-facio-cutaneous syndrome (Schulz_2008). Different variants causing a change at the same amino acid residue as the variant of interest (i.e. c.785A>G, p.Q262R; c.785A>C, p.Q262P) have been classified as pathogenic/likely pathogenic by our laboratory and in ClinVar, suggesting that the Gln262 residue is functionally important. To our knowledge, no experimental evidence demonstrating an impact on protein function has been reported. A ClinVar submitter (evaluation after 2014) cites the variant as pathogenic. Based on the evidence outlined above, the variant was classified as likely pathogenic. |