Submissions for variant NM_004360.5(CDH1):c.1767T>C (p.Asn589=)

dbSNP: rs763862527

Total submissions: 5

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
GeneDx	RCV000827456	SCV000969106	likely benign	not provided	2018-05-17	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Labcorp Genetics (formerly Invitae), Labcorp	RCV002067455	SCV002441898	likely benign	Hereditary diffuse gastric adenocarcinoma	2024-10-15	criteria provided, single submitter	clinical testing
European Reference Network on Genetic Tumour Risk Syndromes (ERN-GENTURIS), i3s - Instituto de Investigação e Inovação em Saúde, University of Porto	RCV002067455	SCV003926851	uncertain significance	Hereditary diffuse gastric adenocarcinoma	2022-08-01	criteria provided, single submitter	clinical testing	PM2 (PMID: 30311375)
Color Diagnostics, LLC DBA Color Health	RCV003584769	SCV004360496	likely benign	Hereditary cancer-predisposing syndrome	2023-08-15	criteria provided, single submitter	clinical testing
Myriad Genetics, Inc.	RCV002067455	SCV005405553	benign	Hereditary diffuse gastric adenocarcinoma	2024-09-20	criteria provided, single submitter	clinical testing	This variant is considered benign. This variant is a silent/synonymous amino acid change and it is not expected to impact splicing.