ClinVar Miner

Submissions for variant NM_004360.5(CDH1):c.2646C>T (p.Asp882=)

dbSNP: rs1555518315
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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000612448 SCV000727288 likely benign not specified 2018-01-31 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Labcorp Genetics (formerly Invitae), Labcorp RCV001422091 SCV001624631 likely benign Hereditary diffuse gastric adenocarcinoma 2020-09-02 criteria provided, single submitter clinical testing
Myriad Genetics, Inc. RCV001422091 SCV005406723 benign Hereditary diffuse gastric adenocarcinoma 2024-09-24 criteria provided, single submitter clinical testing This variant is considered benign. This variant is a silent/synonymous amino acid change and it is not expected to impact splicing.

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