Submissions for variant NM_004360.5(CDH1):c.408A>G (p.Gln136=)

dbSNP: rs1060501229

Total submissions: 6

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Invitae	RCV000468489	SCV000545415	likely benign	Hereditary diffuse gastric adenocarcinoma	2023-11-07	criteria provided, single submitter	clinical testing
Ambry Genetics	RCV000566934	SCV000668994	likely benign	Hereditary cancer-predisposing syndrome	2015-09-09	criteria provided, single submitter	clinical testing	This alteration is classified as likely benign based on a combination of the following: population frequency, intact protein function, lack of segregation with disease, co-occurrence, RNA analysis, in silico models, amino acid conservation, lack of disease association in case-control studies, and/or the mechanism of disease or impacted region is inconsistent with a known cause of pathogenicity.
Color Diagnostics, LLC DBA Color Health	RCV000566934	SCV000689535	likely benign	Hereditary cancer-predisposing syndrome	2020-09-29	criteria provided, single submitter	clinical testing
PreventionGenetics, part of Exact Sciences	RCV000679576	SCV000806671	uncertain significance	not provided	2017-04-19	criteria provided, single submitter	clinical testing
Women's Health and Genetics/Laboratory Corporation of America, LabCorp	RCV000780097	SCV000917138	likely benign	not specified	2019-08-28	criteria provided, single submitter	clinical testing
GeneDx	RCV000679576	SCV001944112	benign	not provided	2015-07-05	criteria provided, single submitter	clinical testing