ClinVar Miner

Submissions for variant NM_004360.5(CDH1):c.832+9A>T

gnomAD frequency: 0.00001  dbSNP: rs1057521268
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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000442004 SCV000521990 likely benign not specified 2016-11-21 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Labcorp Genetics (formerly Invitae), Labcorp RCV001079128 SCV000637856 likely benign Hereditary diffuse gastric adenocarcinoma 2024-01-21 criteria provided, single submitter clinical testing
Color Diagnostics, LLC DBA Color Health RCV000581288 SCV000689568 likely benign Hereditary cancer-predisposing syndrome 2017-01-09 criteria provided, single submitter clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano RCV003477919 SCV000888039 likely benign not provided 2023-09-21 criteria provided, single submitter clinical testing
Myriad Genetics, Inc. RCV001079128 SCV005406509 likely benign Hereditary diffuse gastric adenocarcinoma 2024-09-16 criteria provided, single submitter clinical testing This variant is considered likely benign. This variant is intronic and is not expected to impact mRNA splicing.

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