Submissions for variant NM_004360.5(CDH1):c.833-17T>C

dbSNP: rs1057520572

Total submissions: 5

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
GeneDx	RCV000431738	SCV000522361	likely benign	not specified	2017-08-10	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Color Diagnostics, LLC DBA Color Health	RCV000580417	SCV000684487	likely benign	Hereditary cancer-predisposing syndrome	2016-03-29	criteria provided, single submitter	clinical testing
Labcorp Genetics (formerly Invitae), Labcorp	RCV002062493	SCV002330745	likely benign	Hereditary diffuse gastric adenocarcinoma	2023-12-22	criteria provided, single submitter	clinical testing
CHEO Genetics Diagnostic Laboratory, Children's Hospital of Eastern Ontario	RCV003150209	SCV003837766	likely benign	Breast and/or ovarian cancer	2021-11-22	criteria provided, single submitter	clinical testing
Myriad Genetics, Inc.	RCV002062493	SCV005405103	likely benign	Hereditary diffuse gastric adenocarcinoma	2024-09-16	criteria provided, single submitter	clinical testing	This variant is considered likely benign. This variant is intronic and is not expected to impact mRNA splicing.