ClinVar Miner

Submissions for variant NM_004360.5(CDH1):c.833-20A>T

gnomAD frequency: 0.00001  dbSNP: rs1057521024
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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000427533 SCV000520557 likely benign not specified 2015-11-05 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Labcorp Genetics (formerly Invitae), Labcorp RCV003766231 SCV004628473 likely benign Hereditary diffuse gastric adenocarcinoma 2023-12-27 criteria provided, single submitter clinical testing
Myriad Genetics, Inc. RCV003766231 SCV005407290 likely benign Hereditary diffuse gastric adenocarcinoma 2024-09-16 criteria provided, single submitter clinical testing This variant is considered likely benign. This variant is intronic and is not expected to impact mRNA splicing.

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