ClinVar Miner

Submissions for variant NM_004360.5(CDH1):c.833-6T>C

dbSNP: rs1399679461
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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000609566 SCV000719559 likely benign not specified 2017-05-16 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Color Diagnostics, LLC DBA Color Health RCV000776625 SCV000912244 likely benign Hereditary cancer-predisposing syndrome 2017-10-08 criteria provided, single submitter clinical testing
Labcorp Genetics (formerly Invitae), Labcorp RCV001500747 SCV001705545 likely benign Hereditary diffuse gastric adenocarcinoma 2023-10-13 criteria provided, single submitter clinical testing
Myriad Genetics, Inc. RCV001500747 SCV005404318 likely benign Hereditary diffuse gastric adenocarcinoma 2024-09-16 criteria provided, single submitter clinical testing This variant is considered likely benign. This variant is intronic and is not expected to impact mRNA splicing.

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