Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Molecular Genetics, |
RCV002225199 | SCV002503754 | uncertain significance | Capillary malformation-arteriovenous malformation 2 | 2020-11-20 | criteria provided, single submitter | clinical testing | This sequence change is predicted to replace arginine with tryptophan at codon 722 of the EPHB4 protein (p.(Arg722Trp)). The arginine residue is invariant across species (100 vertebrates, UCSC), and is located in a helical region in the protein kinase domain. There is a large physicochemical difference between arginine and tryptophan. The variant is absent in a large population cohort (gnomAD v2.1 and v3.0), and has not been reported in the relevant medical literature or databases. Multiple lines of computational evidence predict a deleterious effect for the missense substitution (4/6 algorithms). Based on the classification scheme RMH Modified ACMG Guidelines v1.3.0, this variant is classified as a VARIANT OF UNCERTAIN SIGNIFICANCE. Following criteria are met: PM2_Supporting, PP3. |