ClinVar Miner

Submissions for variant NM_004484.4(GPC3):c.1566C>T (p.Phe522=)

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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Labcorp Genetics (formerly Invitae), Labcorp RCV002590662 SCV002955660 likely benign Wilms tumor 1 2023-08-17 criteria provided, single submitter clinical testing
PreventionGenetics, part of Exact Sciences RCV003971336 SCV004782860 likely benign GPC3-related disorder 2022-08-16 no assertion criteria provided clinical testing This variant is classified as likely benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).

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