ClinVar Miner

Submissions for variant NM_004484.4(GPC3):c.1665C>T (p.Leu555=)

dbSNP: rs1248944051
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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Labcorp Genetics (formerly Invitae), Labcorp RCV000868124 SCV001009421 likely benign Wilms tumor 1 2023-11-24 criteria provided, single submitter clinical testing
PreventionGenetics, part of Exact Sciences RCV003975415 SCV004795377 likely benign GPC3-related disorder 2023-10-24 no assertion criteria provided clinical testing This variant is classified as likely benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).

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