ClinVar Miner

Submissions for variant NM_004526.4(MCM2):c.1656G>A (p.Ser552=)

gnomAD frequency: 0.00319  dbSNP: rs138708920
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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Labcorp Genetics (formerly Invitae), Labcorp RCV000923678 SCV001069163 benign not provided 2025-01-18 criteria provided, single submitter clinical testing
GeneDx RCV000923678 SCV002008511 likely benign not provided 2021-03-04 criteria provided, single submitter clinical testing
PreventionGenetics, part of Exact Sciences RCV003923305 SCV004738922 benign MCM2-related disorder 2019-03-13 no assertion criteria provided clinical testing This variant is classified as benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).

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