ClinVar Miner

Submissions for variant NM_004985.5(KRAS):c.411T>C (p.Tyr137=)

gnomAD frequency: 0.00001  dbSNP: rs752731198
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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV001594067 SCV001825361 likely benign not provided 2020-10-08 criteria provided, single submitter clinical testing
Labcorp Genetics (formerly Invitae), Labcorp RCV002070454 SCV002449116 likely benign RASopathy 2025-01-30 criteria provided, single submitter clinical testing
Ambry Genetics RCV004995964 SCV005613877 likely benign Cardiovascular phenotype 2024-10-15 criteria provided, single submitter clinical testing This alteration is classified as likely benign based on a combination of the following: seen in unaffected individuals, population frequency, intact protein function, lack of segregation with disease, co-occurrence, RNA analysis, in silico models, amino acid conservation, lack of disease association in case-control studies, and/or the mechanism of disease or impacted region is inconsistent with a known cause of pathogenicity.
PreventionGenetics, part of Exact Sciences RCV004551945 SCV004714093 likely benign KRAS-related disorder 2020-09-04 no assertion criteria provided clinical testing This variant is classified as likely benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).

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