ClinVar Miner

Submissions for variant NM_004985.5(KRAS):c.451-10T>C

dbSNP: rs876657481
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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine RCV000218226 SCV000270324 likely benign not specified 2016-02-19 criteria provided, single submitter clinical testing c.451-10T>C in intron 4 of KRAS: This variant is not expected to have clinical s ignificance because a T>C change at this position does not diverge from the spli ce consensus sequence and is therefore unlikely to impact splicing.
Labcorp Genetics (formerly Invitae), Labcorp RCV005090062 SCV005806048 likely benign RASopathy 2024-09-17 criteria provided, single submitter clinical testing

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