ClinVar Miner

Submissions for variant NM_004985.5(KRAS):c.451-5617= (rs4362222)

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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine RCV000039808 SCV000063497 benign not specified 2012-07-31 criteria provided, single submitter clinical testing
GeneDx RCV000039808 SCV000170022 benign not specified 2014-01-17 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
PreventionGenetics,PreventionGenetics RCV000039808 SCV000315214 benign not specified criteria provided, single submitter clinical testing
Mendelics RCV000988801 SCV001138665 benign Noonan syndrome 3 2019-05-28 criteria provided, single submitter clinical testing
Baylor Genetics RCV000149847 SCV000196692 benign Rasopathy no assertion criteria provided clinical testing Variant classified using ACMG guidelines

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