Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Seattle Children's Hospital Molecular Genetics Laboratory, |
RCV004720195 | SCV005326333 | likely pathogenic | Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency | criteria provided, single submitter | clinical testing | The p.Cys58Tyr variant substitutes the cysteine at amino acid position 58 with a tyrosine in the Ig-like V-type domain of the CTLA4 protein. While this variant appears to be novel, other changes have been reported at the same amino acid position (p.Cys58Gly and p.Cys58Phe). The p.Cys58Gly variant was identified in one individual in a study of pediatric Evan's syndrome, but clinical details were provided at the individual patient level (PMID: 30940614, Patient P14). The p.Cys58Gly variant was predicted to cause loss-of-function. The p.Cys58Phe variant was identified in an adult with respiratory infections, cytopenia, common variable immune deficiency, hypogammaglobulinemia, low IgG, IgM, and IgA levels, and bacterial infections (PMID: 29729943, Patient ID: DDD.II.1, Supplemental Table S1). |