ClinVar Miner

Submissions for variant NM_005228.5(EGFR):c.2309_2310insGTC (p.Asp770delinsGluSer)

dbSNP: rs1554350382
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Total submissions: 1
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Molecular Diagnostics, Rajiv Gandhi Cancer Institute & Research Center RCV000595622 SCV000678248 likely pathogenic Lung adenocarcinoma 2017-12-12 criteria provided, single submitter clinical testing In-frame insertion of 'GTC' in exon 20 of EGFR is a negative predictor of drug response to anti EGFR TKIs. This inference is being drawn based upon similar insertions in this region of exon 20.

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