Total submissions: 7
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Pharm |
RCV000211323 | SCV000268169 | drug response | gefitinib response - Efficacy | 2021-03-24 | reviewed by expert panel | curation | PharmGKB Level of Evidence 1A: Level 1A clinical annotations describe variant-drug combinations that have variant-specific prescribing guidance available in a current clinical guideline annotation or an FDA-approved drug label annotation. Annotations of drug labels or clinical guidelines must give prescribing guidance for specific variants (e.g. CYP2C9*3, HLA-B*57:01) or provide mapping from defined allele functions to diplotypes and phenotypes to be used as supporting evidence for a level 1A clinical annotation. Level 1A clinical annotations must also be supported by at least one publication in addition to a clinical guideline or drug label with variant-specific prescribing guidance. |
Mendelics | RCV000987885 | SCV001137371 | pathogenic | Lung carcinoma | 2019-05-28 | criteria provided, single submitter | clinical testing | |
Liquid Biopsy and Cancer Interception Group, |
RCV000418019 | SCV003806315 | pathogenic | Lung adenocarcinoma | 2022-06-06 | criteria provided, single submitter | research | |
OMIM | RCV000018083 | SCV000038362 | drug response | Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, somatic | 2005-05-19 | no assertion criteria provided | literature only | |
OMIM | RCV000018084 | SCV000038363 | drug response | Adenocarcinoma of lung, response to tyrosine kinase inhibitor in, somatic | 2005-05-19 | no assertion criteria provided | literature only | |
Laboratory for Molecular Medicine, |
RCV000150629 | SCV000197954 | drug response | Tyrosine kinase inhibitor response | 2006-10-28 | no assertion criteria provided | clinical testing | |
Key Laboratory of Carcinogenesis and Cancer Invasion, |
RCV000418019 | SCV004042724 | likely pathogenic | Lung adenocarcinoma | no assertion criteria provided | clinical testing |