ClinVar Miner

Submissions for variant NM_005228.5(EGFR):c.2582T>G (p.Leu861Arg)

dbSNP: rs121913444
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Total submissions: 1
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine RCV000038443 SCV000062115 uncertain significance not specified 2013-06-17 criteria provided, single submitter clinical testing The 2582T>G (L861R) variant has been previously identified in a NSCLC tumor and one patient with this variant was reported to have stable disease after treatment with Gefitinib (Yang 2008). However, this single case is not sufficient evidence to predict the likelihood of responsiveness in this individual. Additional information is needed to clarify the clinical significance of this variant.

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