ClinVar Miner

Submissions for variant NM_005343.4(HRAS):c.-10C>T (rs41294870)

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Total submissions: 6
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories RCV000509255 SCV000603968 benign not provided 2017-05-12 criteria provided, single submitter clinical testing
GeneDx RCV000154268 SCV000168831 benign not specified 2012-01-24 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
GenomeConnect, ClinGen RCV000509255 SCV000607340 not provided not provided no assertion provided phenotyping only GenomeConnect assertions are reported exactly as they appear on the patient-provided report from the testing laboratory. GenomeConnect staff make no attempt to reinterpret the clinical significance of the variant.
Invitae RCV000464583 SCV000560892 benign Costello syndrome 2016-12-29 criteria provided, single submitter clinical testing
Laboratory for Molecular Medicine,Partners HealthCare Personalized Medicine RCV000154268 SCV000203926 benign not specified 2007-05-29 no assertion criteria provided clinical testing
PreventionGenetics RCV000154268 SCV000311008 benign not specified criteria provided, single submitter clinical testing

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