Submissions for variant NM_005343.4(HRAS):c.-10C>T

gnomAD frequency: 0.03593  dbSNP: rs41294870

Total submissions: 11

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
GeneDx	RCV000154268	SCV000168831	benign	not specified	2012-01-24	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
PreventionGenetics, part of Exact Sciences	RCV000154268	SCV000311008	benign	not specified		criteria provided, single submitter	clinical testing
Invitae	RCV002512524	SCV000560892	benign	Costello syndrome	2022-11-22	criteria provided, single submitter	clinical testing
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories	RCV000509255	SCV000603968	benign	not provided	2023-11-29	criteria provided, single submitter	clinical testing
Genome Diagnostics Laboratory, The Hospital for Sick Children	RCV001813385	SCV002060508	benign	Noonan syndrome and Noonan-related syndrome	2021-06-16	criteria provided, single submitter	clinical testing
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine	RCV000154268	SCV000203926	benign	not specified	2007-05-29	no assertion criteria provided	clinical testing
GenomeConnect, ClinGen	RCV000509255	SCV000607340	not provided	not provided		no assertion provided	phenotyping only	GenomeConnect assertions are reported exactly as they appear on the patient-provided report from the testing laboratory. GenomeConnect staff make no attempt to reinterpret the clinical significance of the variant.
Department of Pathology and Laboratory Medicine, Sinai Health System	RCV000154268	SCV001550027	benign	not specified		no assertion criteria provided	clinical testing	LB/B > 4 on ClinVar or LB/B > 2 Rep
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen	RCV000154268	SCV001741856	benign	not specified		no assertion criteria provided	clinical testing
Clinical Genetics, Academic Medical Center	RCV000154268	SCV001917883	benign	not specified		no assertion criteria provided	clinical testing
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center	RCV000154268	SCV001966845	benign	not specified		no assertion criteria provided	clinical testing