ClinVar Miner

Submissions for variant NM_005343.4(HRAS):c.451-5C>T

dbSNP: rs370181298
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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV001698422 SCV000726912 likely benign not provided 2021-06-18 criteria provided, single submitter clinical testing
Labcorp Genetics (formerly Invitae), Labcorp RCV000637310 SCV000758761 likely benign Costello syndrome 2024-01-22 criteria provided, single submitter clinical testing
Ambry Genetics RCV004024985 SCV003611204 uncertain significance Cardiovascular phenotype 2022-06-17 criteria provided, single submitter clinical testing The c.451-5C>T intronic alteration consists of a C to T substitution 5 nucleotides before exon 5 (coding exon 4) of the HRAS gene. Based on insufficient or conflicting evidence, the clinical significance of this alteration remains unclear.

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