ClinVar Miner

Submissions for variant NM_005432.4(XRCC3):c.722C>T (p.Thr241Met)

gnomAD frequency: 0.30066  dbSNP: rs861539
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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV003546454 SCV004274737 benign not provided 2023-09-08 criteria provided, single submitter clinical testing
PreventionGenetics, part of Exact Sciences RCV003974815 SCV004790914 benign XRCC3-related condition 2019-10-17 criteria provided, single submitter clinical testing This variant is classified as benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).
OMIM RCV000009500 SCV000029718 risk factor Melanoma, cutaneous malignant, susceptibility to, 6 2000-10-15 no assertion criteria provided literature only

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