ClinVar Miner

Submissions for variant NM_005562.3(LAMC2):c.503+1G>C

dbSNP: rs1057516410
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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Counsyl RCV000410904 SCV000485621 likely pathogenic Junctional epidermolysis bullosa gravis of Herlitz 2016-01-18 criteria provided, single submitter clinical testing
Invitae RCV001865262 SCV002266182 likely pathogenic not provided 2021-03-23 criteria provided, single submitter clinical testing This sequence change affects a donor splice site in intron 4 of the LAMC2 gene. It is expected to disrupt RNA splicing. Variants that disrupt the donor or acceptor splice site typically lead to a loss of protein function (PMID: 16199547), and loss-of-function variants in LAMC2 are known to be pathogenic (PMID: 11907499, 16473856). In summary, the currently available evidence indicates that the variant is pathogenic, but additional data are needed to prove that conclusively. Therefore, this variant has been classified as Likely Pathogenic. Algorithms developed to predict the effect of sequence changes on RNA splicing suggest that this variant may disrupt the consensus splice site, but this prediction has not been confirmed by published transcriptional studies. This variant has not been reported in the literature in individuals with LAMC2-related conditions. ClinVar contains an entry for this variant (Variation ID: 370336). This variant is not present in population databases (ExAC no frequency).

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