Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Broad Center for Mendelian Genomics, |
RCV002227843 | SCV002507001 | pathogenic | Congenital myasthenic syndrome 5 | 2022-05-04 | criteria provided, single submitter | curation | The homozygous p.Trp354Ter variant in COLQ was identified by our study in 1 individual with congenital myasthenic syndrome 5. The variant has not been previously reported in individuals with congenital myasthenic syndrome 5 and was absent from large population studies. This nonsense variant leads to a premature termination codon at position 354, which is predicted to lead to a truncated or absent protein. Loss of function of the COLQ gene is an established disease mechanism in autosomal recessive congenital myasthenic syndrome 5. In summary, this variant meets criteria to be classified as pathogenic for congenital myasthenic syndrome 5 in an autosomal recessive manner based on the predicted loss of function effect and absence of this variant from large population studies. ACMG/AMP Criteria applied: PVS1, PM2, PM3_supporting (Richards 2015). |