Total submissions: 2
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Gene |
RCV001546387 | SCV001765893 | pathogenic | not provided | 2024-09-26 | criteria provided, single submitter | clinical testing | Not observed at significant frequency in large population cohorts (gnomAD); Missense variants in this gene are a common cause of disease and they are underrepresented in the general population; In silico analysis supports that this missense variant has a deleterious effect on protein structure/function; This variant is associated with the following publications: (PMID: 25059107, 24860126, 26130693, 33726816) |
Prevention |
RCV003908893 | SCV004722963 | uncertain significance | TUBA1A-related disorder | 2024-01-02 | no assertion criteria provided | clinical testing | The TUBA1A c.640C>T variant is predicted to result in the amino acid substitution p.Arg214Cys. This variant has been reported de novo in an individual with an unknown phenotype in a large whole genome sequencing cohort (Table S7, Stranneheim et al 2021. PubMed ID: 33726816). This variant has not been reported in a large population database, indicating this variant is rare. A different missense variant at the same amino acid (p.Arg214His) has been reported de novo in multiple individuals with TUBA1A-related tubulinopathies (Bahi-Buisson et al. 2014. PubMed ID: 24860126; Hebebrand et al. 2019. PubMed ID: 30744660) and is interpreted as pathogenic in ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/variation/372542/). Although we suspect that the p.Arg214Cys variant may be pathogenic, the clinical significance of this variant is uncertain at this time due to the absence of conclusive functional and genetic evidence. |