Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Labcorp Genetics |
RCV001352011 | SCV001546528 | uncertain significance | Cowden syndrome | 2020-07-16 | criteria provided, single submitter | clinical testing | In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance. This variant disrupts the p.His1047 amino acid residue in PIK3CA. Other variant(s) that disrupt this residue have been determined to be pathogenic (PMID: 25599672, 27631024, 28502725, 22658544, 23100325). This suggests that this residue is clinically significant, and that variants that disrupt this residue are likely to be disease-causing. Algorithms developed to predict the effect of missense changes on protein structure and function are either unavailable or do not agree on the potential impact of this missense change (SIFT: "Not Available"; PolyPhen-2: "Possibly Damaging"; Align-GVGD: "Not Available"). This variant has not been reported in the literature in individuals with PIK3CA-related conditions. This variant is not present in population databases (ExAC no frequency). This sequence change replaces histidine with isoleucine at codon 1047 of the PIK3CA protein (p.His1047Ile). The histidine residue is highly conserved and there is a moderate physicochemical difference between histidine and isoleucine. |