ClinVar Miner

Submissions for variant NM_006231.3(POLE):c.3378+7G>T (rs755370377)

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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV000226840 SCV000289329 benign Colorectal cancer, susceptibility to, 12 2019-12-27 criteria provided, single submitter clinical testing
Counsyl RCV000226840 SCV000489720 likely benign Colorectal cancer, susceptibility to, 12 2016-11-10 criteria provided, single submitter clinical testing
GeneDx RCV000603287 SCV000713986 likely benign not specified 2017-10-25 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Quest Diagnostics Nichols Institute San Juan Capistrano RCV000759287 SCV000888526 benign not provided 2018-04-26 criteria provided, single submitter clinical testing

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