ClinVar Miner

Submissions for variant NM_006231.3(POLE):c.4245C>T (p.Asn1415=) (rs778896278)

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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000568016 SCV000671622 likely benign Hereditary cancer-predisposing syndrome 2016-09-20 criteria provided, single submitter clinical testing Lines of evidence used in support of classification: Synonymous alterations with insufficient evidence to classify as benign
Invitae RCV000545729 SCV000653280 likely benign Colorectal cancer, susceptibility to, 12 2017-02-16 criteria provided, single submitter clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano RCV000508075 SCV000602044 likely benign not specified 2017-01-17 criteria provided, single submitter clinical testing

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