ClinVar Miner

Submissions for variant NM_006231.4(POLE):c.6331-8C>T (rs769766403)

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Total submissions: 6
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV000228013 SCV000289455 likely benign Colorectal cancer, susceptibility to, 12 2019-12-31 criteria provided, single submitter clinical testing
GeneDx RCV000420076 SCV000530592 likely benign not specified 2018-01-10 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Quest Diagnostics Nichols Institute San Juan Capistrano RCV000420076 SCV000602080 likely benign not specified 2016-12-09 criteria provided, single submitter clinical testing
Counsyl RCV000228013 SCV000786441 likely benign Colorectal cancer, susceptibility to, 12 2018-05-02 criteria provided, single submitter clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano RCV000760034 SCV000889784 benign not provided 2018-03-29 criteria provided, single submitter clinical testing
Mendelics RCV000228013 SCV001138856 likely benign Colorectal cancer, susceptibility to, 12 2019-05-28 criteria provided, single submitter clinical testing

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