Submissions for variant NM_006361.6(HOXB13):c.459T>G (p.Gly153=)

dbSNP: rs1597934161

Total submissions: 4

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Ambry Genetics	RCV002336749	SCV002637659	likely benign	Hereditary cancer-predisposing syndrome	2020-06-18	criteria provided, single submitter	clinical testing	This alteration is classified as likely benign based on a combination of the following: seen in unaffected individuals, population frequency, intact protein function, lack of segregation with disease, co-occurrence, RNA analysis, in silico models, amino acid conservation, lack of disease association in case-control studies, and/or the mechanism of disease or impacted region is inconsistent with a known cause of pathogenicity.
Labcorp Genetics (formerly Invitae), Labcorp	RCV002538365	SCV003255071	likely benign	not provided	2024-09-18	criteria provided, single submitter	clinical testing
Myriad Genetics, Inc.	RCV003316815	SCV004017709	benign	Prostate cancer, hereditary, 9	2023-04-05	criteria provided, single submitter	clinical testing	This variant is considered benign. This variant is a silent/synonymous amino acid change and it is not expected to impact splicing.
Laboratory of Virology, Microbiology, Quality and Medical Biotechnologies, Faculty of Sciences and Techniques - Mohammedia, Hassan II University of Casablanca	RCV000856078	SCV000994069	uncertain significance	Prostate cancer, hereditary, 1		no assertion criteria provided	clinical testing