ClinVar Miner

Submissions for variant NM_006440.5(TXNRD2):c.110A>T (p.Gln37Leu) (rs148092370)

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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV000226062 SCV000289535 benign Primary dilated cardiomyopathy 2020-11-14 criteria provided, single submitter clinical testing
Ambry Genetics RCV000245207 SCV000318812 benign Cardiovascular phenotype 2016-06-15 criteria provided, single submitter clinical testing In silico models in agreement (benign);Subpopulation frequency in support of benign classification
GeneDx RCV000422509 SCV000528231 benign not specified 2017-07-12 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.

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