ClinVar Miner

Submissions for variant NM_006440.5(TXNRD2):c.903C>T (p.Thr301=) (rs35695986)

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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000247540 SCV000318615 likely benign Cardiovascular phenotype 2016-09-07 criteria provided, single submitter clinical testing Synonymous alterations with insufficient evidence to classify as benign
GeneDx RCV000842503 SCV000984526 likely benign not provided 2018-04-30 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae RCV001398752 SCV001600527 likely benign Primary dilated cardiomyopathy 2020-11-10 criteria provided, single submitter clinical testing

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